Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

Chk2/hcds1, the human homolog of the Saccharomyces cerevisiae RAD53/SPK1 and Schizosaccharomyces pombe cds1 DNA damage checkpoint genes, encodes a protein kinase that is post-translationally modified after DNA damage. Like its yeast homologs, the Chk2/hCds1 protein phosphorylates Cdc25C in vitro, su...

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Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Genes Dev
Prif Awduron:	Chehab, Nabil H., Malikzay, Asra, Appel, Michael, Halazonetis, Thanos D.
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Cold Spring Harbor Laboratory Press 2000
Pynciau:	Research Paper
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10673500/
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