The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

Three-dimensional (3D) cultures are a valuable platform to study acquired multicellular apoptotic resistance of cancer. We used spheroids of cell lines and actual tumor to study resistance to the proteasome inhibitor bortezomib in mesothelioma, a highly chemoresistant tumor. Spheroids from mesotheli...

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Bibliografiske detaljer
Main Authors: Barbone, D, Ryan, J A, Kolhatkar, N, Chacko, A D, Jablons, D M, Sugarbaker, D J, Bueno, R, Letai, A G, Coussens, L M, Fennell, D A, Broaddus, V C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169000/
https://ncbi.nlm.nih.gov/pubmed/21697949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.58
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