Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species

Por Fennell, D A, Corbo, M, Pallaska, A, Cotter, F E
Publicado em 2001

Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells

Por Okaro, A C, Fennell, D A, Corbo, M, Davidson, B R, Cotter, F E
Publicado em 2002

Biomarkers of clinical benefit for anti-epidermal growth factor receptor agents in patients with non-small-cell lung cancer

Por Pallis, A G, Fennell, D A, Szutowicz, E, Leighl, N B, Greillier, L, Dziadziuszko, R
Publicado em 2011

Wnt–β-catenin–Tcf-4 signalling-modulated invasiveness is dependent on osteopontin expression in breast cancer

Por Ravindranath, A, Yuen, H-F, Chan, K-K, Grills, C, Fennell, D A, Lappin, T R, El-Tanani, M
Publicado em 2011

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK

Por McCoy, F, Hurwitz, J, McTavish, N, Paul, I, Barnes, C, O'Hagan, B, Odrzywol, K, Murray, J, Longley, D, McKerr, G, Fennell, D A
Publicado em 2010

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

Por Crawford, N, Stasik, I, Holohan, C, Majkut, J, McGrath, M, Johnston, P G, Chessari, G, Ward, G A, Waugh, D J, Fennell, D A, Longley, D B
Publicado em 2013

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

Por Barbone, D, Ryan, J A, Kolhatkar, N, Chacko, A D, Jablons, D M, Sugarbaker, D J, Bueno, R, Letai, A G, Coussens, L M, Fennell, D A, Broaddus, V C
Publicado em 2011

Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer

Por Paul, I, Chacko, A D, Stasik, I, Busacca, S, Crawford, N, McCoy, F, McTavish, N, Wilson, B, Barr, M, O'Byrne, K J, Longley, D B, Fennell, D A
Publicado em 2012

Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo

Por Manente, A G, Valenti, D, Pinton, G, Jithesh, P V, Daga, A, Rossi, L, Gray, S G, O'Byrne, K J, Fennell, D A, Vacca, R A, Nilsson, S, Mutti, L, Moro, L
Publicado em 2013

Resistance to HSP90 inhibition involving loss of MCL1 addiction

Por Busacca, S, Law, E W P, Powley, I R, Proia, D A, Sequeira, M, Le Quesne, J, Klabatsa, A, Edwards, J M, Matchett, K B, Luo, J L, Pringle, J H, El-Tanani, M, MacFarlane, M, Fennell, D A
Publicado no Oncogene (2016)

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer

Por Riley, J S, Hutchinson, R, McArt, D G, Crawford, N, Holohan, C, Paul, I, Van Schaeybroeck, S, Salto-Tellez, M, Johnston, P G, Fennell, D A, Gately, K, O'Byrne, K, Cummins, R, Kay, E, Hamilton, P, Stasik, I, Longley, D B
Publicado em 2013