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Mammalian Target of Rapamycin Contributes to the Acquired Apoptotic Resistance of Human Mesothelioma Multicellular Spheroids

When grown as three-dimensional structures, tumor cells can acquire an additional multicellular resistance to apoptosis that may mimic the chemoresistance found in solid tumors. We developed a multicellular spheroid model of malignant mesothelioma to investigate molecular mechanisms of acquired apop...

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Main Authors: Barbone, Dario, Yang, Tsung-Ming, Morgan, Jeffrey R., Gaudino, Giovanni, Broaddus, V. Courtney
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442321/
https://ncbi.nlm.nih.gov/pubmed/18339627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709698200
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