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Deletion of IA-2 and/or IA-2β Decreases Insulin Secretion by Reducing the Number of Dense Core Vesicles

AIMS/HYPOTHESIS: IA-2 and IA-2β are dense core vesicle (DCV) transmembrane proteins and major autoantigens in type 1 diabetes. The present experiments were initiated to test the hypothesis that the knockout of these genes impairs the secretion of insulin by reducing the number of DCV. METHODS: Insul...

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Autors principals: Cai, T., Hirai, H., Zhang, G., Zhang, M., Takahashi, N., Kasai, H., Satin, L. S., Leapman, R. D., Notkins, A. L.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168514/
https://ncbi.nlm.nih.gov/pubmed/21732083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-011-2221-6
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