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Deletion of IA-2 and/or IA-2β Decreases Insulin Secretion by Reducing the Number of Dense Core Vesicles
AIMS/HYPOTHESIS: IA-2 and IA-2β are dense core vesicle (DCV) transmembrane proteins and major autoantigens in type 1 diabetes. The present experiments were initiated to test the hypothesis that the knockout of these genes impairs the secretion of insulin by reducing the number of DCV. METHODS: Insul...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3168514/ https://ncbi.nlm.nih.gov/pubmed/21732083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-011-2221-6 |
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