Targeting the Notch Ligand Jagged1 in Both Tumor Cells and Stroma in Ovarian Cancer

PURPOSE: Jagged1, a Notch ligand, is expressed on both tumor epithelial and endothelial cells, and therefore may be amenable to dual targeting of the tumor stroma and malignant cell compartments of the tumor microenvironment. EXPERIMENTAL DESIGN: We describe in vitro effects of targeting of Jagged1...

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Main Authors: Steg, Adam D., Katre, Ashwini A., Goodman, Blake, Han, Hee-Dong, Nick, Alpa M., Stone, Rebecca L., Coleman, Robert L., Alvarez, Ronald D., Lopez-Berestein, Gabriel, Sood, Anil K., Landen, Charles N.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166981/
https://ncbi.nlm.nih.gov/pubmed/21753153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0432
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