Discovery, Synthesis, and Structure Activity Relationship Development of a Series of N-(4-acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu(4)) with CNS Exposure in Rats

অনুরূপ উপাদানগুলি

• Discovery, Synthesis, SAR Development of a Series of N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu(4)) with Oral Efficacy in an anti-Parkinsonian Animal Model
  অনুযায়ী: Jones, Carrie K., অন্যান্য
  প্রকাশিত: (2011)
• Synthesis and Evaluation of a Series of Heterobiaryl Amides that are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)
  অনুযায়ী: Engers, Darren W., অন্যান্য
  প্রকাশিত: (2009)
• Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu(4)
  অনুযায়ী: Cheung, Yiu-Yin, অন্যান্য
  প্রকাশিত: (2011)
• Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu(4)) antagonist: Unexpected ‘molecular switch’ from a closely related mGlu(4) positive allosteric modulator
  অনুযায়ী: Utley, Thomas, অন্যান্য
  প্রকাশিত: (2011)
• Antidepressant potential of metabotropic glutamate receptor mGlu(2) and mGlu(3) negative allosteric modulators
  অনুযায়ী: Joffe, Max E., অন্যান্য
  প্রকাশিত: (2018)