Discovery, Synthesis, and Structure Activity Relationship Development of a Series of N-(4-acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu(4)) with CNS Exposure in Rats

Lignende værker

• Discovery, Synthesis, SAR Development of a Series of N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu(4)) with Oral Efficacy in an anti-Parkinsonian Animal Model
  af: Jones, Carrie K., et al.
  Udgivet: (2011)
• Synthesis and Evaluation of a Series of Heterobiaryl Amides that are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)
  af: Engers, Darren W., et al.
  Udgivet: (2009)
• Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu(4)
  af: Cheung, Yiu-Yin, et al.
  Udgivet: (2011)
• Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu(4)) antagonist: Unexpected ‘molecular switch’ from a closely related mGlu(4) positive allosteric modulator
  af: Utley, Thomas, et al.
  Udgivet: (2011)
• Antidepressant potential of metabotropic glutamate receptor mGlu(2) and mGlu(3) negative allosteric modulators
  af: Joffe, Max E., et al.
  Udgivet: (2018)