Discovery, Synthesis, and Structure Activity Relationship Development of a Series of N-(4-acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu(4)) with CNS Exposure in Rats

Herein we report the discovery, synthesis and evaluation of a series of N-(4-acetamido)-phenylpicolinamides as positive allosteric modulators of mGlu(4).() Compounds from the series show submicromolar potency at both human and rat mGlu(4). In addition, pharmacokinetic studies utilizing subcutaneous...

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Autores principales: Engers, Darren W., Field, Julie R., Le, Uyen, Zhou, Ya, Bolinger, Julie D., Zamorano, Rocio, Blobaum, Anna L., Jones, Carrie K., Jadhav, Satyawan, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166797/
https://ncbi.nlm.nih.gov/pubmed/21247167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101271s
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