Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus

We have investigated the mechanism, structural correlates, and cis-acting elements involved in chromatin opening and gene activation, using the human β-globin locus as a model. Full transcriptional activity of the human β-globin locus requires the locus control region (LCR), composed of a series of...

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Veröffentlicht in:	Genes Dev
Hauptverfasser:	Schübeler, Dirk, Francastel, Claire, Cimbora, Daniel M., Reik, Andreas, Martin, David I.K., Groudine, Mark
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 2000
Schlagworte:	Research Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316536/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10783166/
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