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Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus

We have investigated the mechanism, structural correlates, and cis-acting elements involved in chromatin opening and gene activation, using the human β-globin locus as a model. Full transcriptional activity of the human β-globin locus requires the locus control region (LCR), composed of a series of...

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Udgivet i:Genes Dev
Principais autores: Schübeler, Dirk, Francastel, Claire, Cimbora, Daniel M., Reik, Andreas, Martin, David I.K., Groudine, Mark
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2000
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316536/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10783166/
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