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Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus

We have investigated the mechanism, structural correlates, and cis-acting elements involved in chromatin opening and gene activation, using the human β-globin locus as a model. Full transcriptional activity of the human β-globin locus requires the locus control region (LCR), composed of a series of...

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Main Authors: Schübeler, Dirk, Francastel, Claire, Cimbora, Daniel M., Reik, Andreas, Martin, David I.K., Groudine, Mark
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2000
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC316536/
https://ncbi.nlm.nih.gov/pubmed/10783166
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