The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells

Studies in many systems have led to the model that the human β-globin locus control region (LCR) regulates the transcription, chromatin structure, and replication properties of the β-globin locus. However the precise mechanisms of this regulation are unknown. We have developed strategies to use homo...

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Bibliografiske detaljer
Main Authors: Reik, Andreas, Telling, Agnes, Zitnik, Galynn, Cimbora, Daniel, Epner, Elliot, Groudine, Mark
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1998
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC109185/
https://ncbi.nlm.nih.gov/pubmed/9742116
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