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Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and differentiation during animal development and adult homeostasis. Here, we show that human Nedd4 (Nedd4-1), an E3 ubiquitin ligase comprised of a C2 domain, 4 WW domains, and a Hect domain, regulates endocyto...

詳細記述

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書誌詳細
主要な著者: Persaud, Avinash, Alberts, Philipp, Hayes, Madeline, Guettler, Sebastian, Clarke, Ian, Sicheri, Frank, Dirks, Peter, Ciruna, Brian, Rotin, Daniela
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160656/
https://ncbi.nlm.nih.gov/pubmed/21765395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.234
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