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Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and differentiation during animal development and adult homeostasis. Here, we show that human Nedd4 (Nedd4-1), an E3 ubiquitin ligase comprised of a C2 domain, 4 WW domains, and a Hect domain, regulates endocyto...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2011
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160656/ https://ncbi.nlm.nih.gov/pubmed/21765395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.234 |
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