Ubiquitylation‐dependent oligomerization regulates activity of Nedd4 ligases

Ubiquitylation controls protein function and degradation. Therefore, ubiquitin ligases need to be tightly controlled. We discovered an evolutionarily conserved allosteric restraint mechanism for Nedd4 ligases and demonstrated its function with diverse substrates: the yeast soluble proteins Rpn10 and...

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Pubblicato in:EMBO J
Autori principali: Attali, Ilan, Tobelaim, William Sam, Persaud, Avinash, Motamedchaboki, Khatereh, Simpson‐Lavy, Kobi J, Mashahreh, Bayan, Levin‐Kravets, Olga, Keren‐Kaplan, Tal, Pilzer, Inbar, Kupiec, Martin, Wiener, Reuven, Wolf, Dieter A, Rotin, Daniela, Prag, Gali
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437815/
https://ncbi.nlm.nih.gov/pubmed/28069708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694314
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