Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and differentiation during animal development and adult homeostasis. Here, we show that human Nedd4 (Nedd4-1), an E3 ubiquitin ligase comprised of a C2 domain, 4 WW domains, and a Hect domain, regulates endocyto...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Persaud, Avinash, Alberts, Philipp, Hayes, Madeline, Guettler, Sebastian, Clarke, Ian, Sicheri, Frank, Dirks, Peter, Ciruna, Brian, Rotin, Daniela
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2011
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160656/
https://ncbi.nlm.nih.gov/pubmed/21765395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.234
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items