Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila. dFOXO is directly required for transcriptio...

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Auteurs principaux: Alic, Nazif, Andrews, T Daniel, Giannakou, Maria E, Papatheodorou, Irene, Slack, Cathy, Hoddinott, Matthew P, Cochemé, Helena M, Schuster, Eugene F, Thornton, Janet M, Partridge, Linda
Format: Artigo
Langue:Inglês
Publié: European Molecular Biology Organization 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159968/
https://ncbi.nlm.nih.gov/pubmed/21694719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.36
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