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Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing

A challenge of systems biology is to integrate incomplete knowledge on pathways with existing experimental data sets and relate these to measured phenotypes. Research on ageing often generates such incomplete data, creating difficulties in integrating RNA expression with information about biological...

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Detalhes bibliográficos
Main Authors: Papatheodorou, Irene, Ziehm, Matthias, Wieser, Daniela, Alic, Nazif, Partridge, Linda, Thornton, Janet M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519537/
https://ncbi.nlm.nih.gov/pubmed/23251396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050881
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