Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila. dFOXO is directly required for transcriptio...

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Main Authors: Alic, Nazif, Andrews, T Daniel, Giannakou, Maria E, Papatheodorou, Irene, Slack, Cathy, Hoddinott, Matthew P, Cochemé, Helena M, Schuster, Eugene F, Thornton, Janet M, Partridge, Linda
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159968/
https://ncbi.nlm.nih.gov/pubmed/21694719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.36
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