Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila. dFOXO is directly required for transcriptio...

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Main Authors: Alic, Nazif, Andrews, T Daniel, Giannakou, Maria E, Papatheodorou, Irene, Slack, Cathy, Hoddinott, Matthew P, Cochemé, Helena M, Schuster, Eugene F, Thornton, Janet M, Partridge, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159968/
https://ncbi.nlm.nih.gov/pubmed/21694719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.36
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