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AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus()
Activation-induced cytidine deaminase (AID) is induced in B cells during an immune response and is essential for both class switch recombination (CSR) and somatic hypermutation (SHM) of antibody genes. The C terminal 10 amino acids of AID are required for CSR but not for SHM, although their role in...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3159830/ https://ncbi.nlm.nih.gov/pubmed/21804017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101406 |
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