A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs

BACKGROUND: Critical to the development of new drugs for treatment of malaria is the capacity to safely evaluate their activity in human subjects. The approach that has been most commonly used is testing in subjects with natural malaria infection, a methodology that may expose symptomatic subjects t...

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Détails bibliographiques
Auteurs principaux: McCarthy, James S., Sekuloski, Silvana, Griffin, Paul M., Elliott, Suzanne, Douglas, Nanette, Peatey, Chris, Rockett, Rebecca, O'Rourke, Peter, Marquart, Louise, Hermsen, Cornelius, Duparc, Stephan, Möhrle, Jörg, Trenholme, Katharine R., Humberstone, Andrew J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159571/
https://ncbi.nlm.nih.gov/pubmed/21887214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021914
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