Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell-replacement therapies. However one crucial limitation has been the inability to perform experiments under genetically define...

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Autori principali: Soldner, Frank, Laganiere, Josee, Cheng, Albert W, Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I., Myers, Richard H., Lindquist, Susan, Zhang, Lei, Guschin, Dmitry, Fong, Lauren K, Vu, Joe, Meng, Xiangdong, Urnov, Fyodor D., Rebar, Edward J., Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155290/
https://ncbi.nlm.nih.gov/pubmed/21757228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.019
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