Testing of the Topoisomerase 1 Inhibitor Genz644282 by the Pediatric Preclinical Testing Program

BACKGROUND: Genz644282 is a novel non-camptothecin topoisomerase I poison that is in clinical development. PROCEDURES: Genz644282 was tested against the PPTP in vitro panel (0.1 nM–1 μM), and in vivo using three times per week × 2 schedule repeated at day 21 at its maximum tolerated dose (MTD) of 4...

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Hauptverfasser: Houghton, Peter J., Lock, Richard, Carol, Hernan, Morton, Christopher L., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Maris, John M., Billups, Catherine A., Zhang, Mindy X., Madden, Stephen L., Teicher, Beverly A., Smith, Malcolm A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154998/
https://ncbi.nlm.nih.gov/pubmed/21548007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23016
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