Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14

Huntington disease (HD) is caused by polyglutamine expansion in the huntingtin (HTT) protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing palmitoyl acyl transferases (PATs), binds to HTT and robustly palmitoylates HTT at cysteine 214. Mutant HTT exhibits reduced palmi...

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Autori principali: Huang, Kun, Sanders, Shaun S., Kang, Rujun, Carroll, Jeffrey B., Sutton, Liza, Wan, Junmei, Singaraja, Roshni, Young, Fiona B., Liu, Lili, El-Husseini, Alaa, Davis, Nicholas G., Hayden, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153302/
https://ncbi.nlm.nih.gov/pubmed/21636527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr242
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