Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Here we show that huntingtin (htt) is normally palmitoylated at cysteine 214, which is essential for its trafficking and function. The palmitoylation and distribution of htt are...

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Detalhes bibliográficos
Main Authors: Yanai, Anat, Huang, Kun, Kang, Rujun, Singaraja, Roshni R, Arstikaitis, Pamela, Gan, Lu, Orban, Paul C, Mullard, Asher, Cowan, Catherine M, Raymond, Lynn A, Drisdel, Renaldo C, Green, William N, Ravikumar, Brinda, Rubinsztein, David C, El-Husseini, Alaa, Hayden, Michael R
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279235/
https://ncbi.nlm.nih.gov/pubmed/16699508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1702
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