Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Here we show that huntingtin (htt) is normally palmitoylated at cysteine 214, which is essential for its trafficking and function. The palmitoylation and distribution of htt are...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Yanai, Anat, Huang, Kun, Kang, Rujun, Singaraja, Roshni R, Arstikaitis, Pamela, Gan, Lu, Orban, Paul C, Mullard, Asher, Cowan, Catherine M, Raymond, Lynn A, Drisdel, Renaldo C, Green, William N, Ravikumar, Brinda, Rubinsztein, David C, El-Husseini, Alaa, Hayden, Michael R
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2006
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279235/
https://ncbi.nlm.nih.gov/pubmed/16699508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1702
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