H2AX Prevents CtIP-Mediated DNA End Resection and Aberrant Repair in G1-Phase Lymphocytes

DNA double stranded breaks (DSBs) are generated by the RAG endonuclease in all developing lymphocytes as they assemble antigen receptor genes(1). DNA cleavage by RAG occurs only at the G1-phase of the cell cycle and generates two hairpin-sealed DNA (coding) ends that require nucleolytic opening prio...

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Hlavní autoři: Helmink, Beth A., Tubbs, Anthony T., Dorsett, Yair, Bednarski, Jeffrey J., Walker, Laura M., Feng, Zhihui, Sharma, Girdhar, McKinnon, Peter J., Zhang, Junran, Bassing, Craig H., Sleckman, Barry P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150591/
https://ncbi.nlm.nih.gov/pubmed/21160476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09585
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