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The Products of 5-Fluorouridine by the Action of the Pseudouridine Synthase TruB Disfavor One Mechanism and Suggest Another
The pseudouridine synthase TruB handles 5-flurouridine in RNA as a substrate, converting it to two isomeric, hydrated products. Unexpectedly, the two products differ not in the hydrated pyrimidine ring but in the pentose ring, which has been epimerized to arabinose in the minor product. This inversi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150545/ https://ncbi.nlm.nih.gov/pubmed/21744792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201179f |
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