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The Products of 5-Fluorouridine by the Action of the Pseudouridine Synthase TruB Disfavor One Mechanism and Suggest Another

The pseudouridine synthase TruB handles 5-flurouridine in RNA as a substrate, converting it to two isomeric, hydrated products. Unexpectedly, the two products differ not in the hydrated pyrimidine ring but in the pentose ring, which has been epimerized to arabinose in the minor product. This inversi...

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Bibliografiske detaljer
Main Authors: Miracco, Edward J., Mueller, Eugene G.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150545/
https://ncbi.nlm.nih.gov/pubmed/21744792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201179f
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