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Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain

The pseudouridine synthase TruB is responsible for the universally conserved post-transcriptional modification of residue 55 of elongator tRNAs. In addition to the active site, the “thumb,” a peripheral domain unique to the TruB family of enzymes, makes extensive interactions with the substrate. To...

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書目詳細資料
Main Authors: Hoang, Charmaine, Hamilton, Christopher S., Mueller, Eugene G., Ferré-D’Amaré, Adrian R.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279332/
https://ncbi.nlm.nih.gov/pubmed/15987897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051493605
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