Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C: POSSIBLE ROLE OF HEPARAN SULFATE OLIGOSACCHARIDES DERIVED FROM GLYPICAN-1 BY ASCORBATE-INDUCED, NITRIC OXIDE (NO)-CATALYZED DEGRADATION

Amyloid β (Aβ) is generated from the copper- and heparan sulfate (HS)-binding amyloid precursor protein (APP) by proteolytic processing. APP supports S-nitrosylation of the HS proteoglycan glypican-1 (Gpc-1). In the presence of ascorbate, there is NO-catalyzed release of anhydromannose (anMan)-conta...

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Autors principals: Cheng, Fang, Cappai, Roberto, Ciccotosto, Giuseppe D., Svensson, Gabriel, Multhaup, Gerd, Fransson, Lars-Åke, Mani, Katrin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149348/
https://ncbi.nlm.nih.gov/pubmed/21642435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243345
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