ScFv Antibody-induced Translocation of Cell-surface Heparan Sulfate Proteoglycan to Endocytic Vesicles: EVIDENCE FOR HEPARAN SULFATE EPITOPE SPECIFICITY AND ROLE OF BOTH SYNDECAN AND GLYPICAN

Cellular uptake of several viruses and polybasic macromolecules requires the expression of cell-surface heparan sulfate proteoglycan (HSPG) through as yet ill defined mechanisms. We unexpectedly found that among several cell-surface-binding single chain variable fragment (scFv) anti-HS antibody (αHS...

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Détails bibliographiques
Auteurs principaux: Wittrup, Anders, Zhang, Si-He, ten Dam, Gerdy B., van Kuppevelt, Toin H., Bengtson, Per, Johansson, Maria, Welch, Johanna, Mörgelin, Matthias, Belting, Mattias
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Glycobiology and Extracellular Matrices
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781711/
https://ncbi.nlm.nih.gov/pubmed/19783663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036129
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