SPECT imaging of peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies

INTRODUCTION: Amyloid deposits are associated with a broad spectrum of disorders including monoclonal gammopathies, chronic inflammation, and Alzheimer’s disease. In all cases, the amyloid pathology contains, in addition to protein fibrils, a plethora of associated molecules, including high concentr...

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Main Authors: Wall, Jonathan S., Richey, Tina, Stuckey, Alan, Donnell, Robert, Oosterhof, Arie, van Kuppevelt, Toin H., Smits, Nicole C., Kennel, Stephen J.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252471/
https://ncbi.nlm.nih.gov/pubmed/21958847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2011.06.007
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