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Differential distribution of heparan sulfate glycoforms and elevated expression of heparan sulfate biosynthetic enzyme genes in the brain of mucopolysaccharidosis IIIB mice

The primary pathology in mucopolysaccharidosis (MPS) IIIB is lysosomal storage of heparan sulfate (HS) glycosaminoglycans, leading to complex neuropathology and dysfunction, for which the detailed mechanisms remain unclear. Using antibodies that recognize specific HS glycoforms, we demonstrate diffe...

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Detalhes bibliográficos
Main Authors: McCarty, Douglas M., DiRosario, Julianne, Gulaid, Kadra, Killedar, Smruti, Oosterhof, Arie, van Kuppevelt, Toin H., Martin, Paul T., Fu, Haiyan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070083/
https://ncbi.nlm.nih.gov/pubmed/21225451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11011-010-9230-x
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