Differential distribution of heparan sulfate glycoforms and elevated expression of heparan sulfate biosynthetic enzyme genes in the brain of mucopolysaccharidosis IIIB mice

The primary pathology in mucopolysaccharidosis (MPS) IIIB is lysosomal storage of heparan sulfate (HS) glycosaminoglycans, leading to complex neuropathology and dysfunction, for which the detailed mechanisms remain unclear. Using antibodies that recognize specific HS glycoforms, we demonstrate diffe...

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Autori principali: McCarty, Douglas M., DiRosario, Julianne, Gulaid, Kadra, Killedar, Smruti, Oosterhof, Arie, van Kuppevelt, Toin H., Martin, Paul T., Fu, Haiyan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2011
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070083/
https://ncbi.nlm.nih.gov/pubmed/21225451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11011-010-9230-x
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