Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

Sonic Hedgehog (Shh) signaling is crucial for growth, cell fate determination, and axonal guidance in the developing nervous system. Although the receptors Patched (Ptch1) and Smoothened (Smo) are required for Shh signaling, a number of distinct co-receptors contribute to these critical responses to...

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Bibliographische Detailangaben
Hauptverfasser: Witt, Rochelle M., Hecht, Marie-Lyn, Pazyra-Murphy, Maria F., Cohen, Samuel M., Noti, Christian, van Kuppevelt, Toin H., Fuller, Maria, Chan, Jennifer A., Hopwood, John J., Seeberger, Peter H., Segal, Rosalind A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764831/
https://ncbi.nlm.nih.gov/pubmed/23867465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438937
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