Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

Sonic Hedgehog (Shh) signaling is crucial for growth, cell fate determination, and axonal guidance in the developing nervous system. Although the receptors Patched (Ptch1) and Smoothened (Smo) are required for Shh signaling, a number of distinct co-receptors contribute to these critical responses to...

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Bibliografski detalji
Glavni autori: Witt, Rochelle M., Hecht, Marie-Lyn, Pazyra-Murphy, Maria F., Cohen, Samuel M., Noti, Christian, van Kuppevelt, Toin H., Fuller, Maria, Chan, Jennifer A., Hopwood, John J., Seeberger, Peter H., Segal, Rosalind A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Glycobiology and Extracellular Matrices
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764831/
https://ncbi.nlm.nih.gov/pubmed/23867465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438937
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