Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

Sonic Hedgehog (Shh) signaling is crucial for growth, cell fate determination, and axonal guidance in the developing nervous system. Although the receptors Patched (Ptch1) and Smoothened (Smo) are required for Shh signaling, a number of distinct co-receptors contribute to these critical responses to...

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Detalhes bibliográficos
Main Authors: Witt, Rochelle M., Hecht, Marie-Lyn, Pazyra-Murphy, Maria F., Cohen, Samuel M., Noti, Christian, van Kuppevelt, Toin H., Fuller, Maria, Chan, Jennifer A., Hopwood, John J., Seeberger, Peter H., Segal, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764831/
https://ncbi.nlm.nih.gov/pubmed/23867465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438937
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