Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

Sonic Hedgehog (Shh) signaling is crucial for growth, cell fate determination, and axonal guidance in the developing nervous system. Although the receptors Patched (Ptch1) and Smoothened (Smo) are required for Shh signaling, a number of distinct co-receptors contribute to these critical responses to...

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Autors principals: Witt, Rochelle M., Hecht, Marie-Lyn, Pazyra-Murphy, Maria F., Cohen, Samuel M., Noti, Christian, van Kuppevelt, Toin H., Fuller, Maria, Chan, Jennifer A., Hopwood, John J., Seeberger, Peter H., Segal, Rosalind A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764831/
https://ncbi.nlm.nih.gov/pubmed/23867465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438937
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