Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

Sonic Hedgehog (Shh) has dual roles in vertebrate development, as it promotes progenitor cell proliferation and induces tissue patterning. Here we show mitogenic and patterning functions of Shh can be uncoupled from one another. Using a genetic approach to selectively inhibit Shh-proteoglycan intera...

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Autori principali: Chan, Jennifer A., Balasubramanian, Srividya, Witt, Rochelle M., Nazemi, Kellie J., Choi, Yoojin, Pazyra-Murphy, Maria F., Walsh, Carolyn O., Thompson, Margaret, Segal, Rosalind A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676236/
https://ncbi.nlm.nih.gov/pubmed/19287388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2287
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