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Amyloid Precursor Protein (APP)/APP-like Protein 2 (APLP2) Expression Is Required to Initiate Endosome-Nucleus-Autophagosome Trafficking of Glypican-1-derived Heparan Sulfate

Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypican-1 is generated in endosomes by an endogenously or ascorbate-induced S-nitrosothiol-catalyzed reaction. Processing of the amyloid precursor protein (APP) and APP-like protein 2 (APLP2) by β- and γ-secretases...

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Detalhes bibliográficos
Main Authors: Cheng, Fang, Cappai, Roberto, Lidfeldt, Jon, Belting, Mattias, Fransson, Lars-Åke, Mani, Katrin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110294/
https://ncbi.nlm.nih.gov/pubmed/24898256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.552810
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