Suppression of T(H)17 Differentiation and Autoimmunity by a Synthetic ROR Ligand

T helper cells that produce Interleukin-17 (IL-17) (T(H)17 cells) are a recently identified CD4(+) T-cell subset with characterized pathological roles in autoimmune diseases(1–3). The nuclear receptors retinoic acid receptor-related orphan receptors α and γt (RORα and RORγt) have indispensible roles...

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Detalhes bibliográficos
Main Authors: Solt, Laura A., Kumar, Naresh, Nuhant, Philippe, Wang, Yongjun, Lauer, Janelle L., Liu, Jin, Istrate, Monica A., Kamenecka, Theodore M., Roush, William R., Vidović, Dušica, Schürer, Stephan C., Xu, Jihong, Wagoner, Gail, Drew, Paul D., Griffin, Patrick R., Burris, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148894/
https://ncbi.nlm.nih.gov/pubmed/21499262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10075
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