Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

The tumor suppressor p53 has been implicated in the pathogenesis of non-cancer-related conditions such as insulin resistance, cardiac failure, and early aging. In addition, accumulation of p53 has been observed in the hepatocytes of individuals with fibrotic liver diseases, but the significance of t...

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Detalhes bibliográficos
Main Authors: Kodama, Takahiro, Takehara, Tetsuo, Hikita, Hayato, Shimizu, Satoshi, Shigekawa, Minoru, Tsunematsu, Hinako, Li, Wei, Miyagi, Takuya, Hosui, Atsushi, Tatsumi, Tomohide, Ishida, Hisashi, Kanto, Tatsuya, Hiramatsu, Naoki, Kubota, Satoshi, Takigawa, Masaharu, Tomimaru, Yoshito, Tomokuni, Akira, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki, Hayashi, Norio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148730/
https://ncbi.nlm.nih.gov/pubmed/21747166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44957
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