Ortho-Aminoazotoluene activates mouse Constitutive Androstane Receptor (mCAR) and increases expression of mCAR target genes

2'-3-dimethyl-4-aminoazobenzene (ortho-aminoazotoluene, OAT) is an azo dye and a rodent carcinogen that has been evaluated by the International Agency for Research on Cancer (IARC) as a possible (class 2B) human carcinogen. Its mechanism of action remains unclear. We examined the role of the xe...

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Detalhes bibliográficos
Main Authors: Smetanina, Mariya A., Pakharukova, Mariya Y., Kurinna, Svitlana M., Dong, Bingning, Hernandez, Juan P., Moore, David D., Merkulova, Tatyana I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148291/
https://ncbi.nlm.nih.gov/pubmed/21672546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.05.019
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