Direct Antibody Access to the HIV-1 Membrane-Proximal External Region Positively Correlates with Neutralization Sensitivity

On the prereceptor-engaged HIV-1 envelope glycoprotein (Env) spike, epitope access by the membrane-proximal external region (MPER)-directed broadly neutralizing antibodies 2F5 and 4E10 remains unresolved. Data on binding to cell surface Env and entry data using primary isolates suggest inaccessibili...

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Main Authors: Chakrabarti, B. K., Walker, L. M., Guenaga, J. F., Ghobbeh, A., Poignard, P., Burton, D. R., Wyatt, R. T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147955/
https://ncbi.nlm.nih.gov/pubmed/21653673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00756-11
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