Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIV(Ba-L)

The membrane-proximal external region (MPER) of HIV-1, located at the C terminus of the gp41 ectodomain, is conserved and crucial for viral fusion. Three broadly neutralizing monoclonal antibodies (bnMAbs), 2F5, 4E10, and Z13e1, are directed against linear epitopes mapped to the MPER, making this co...

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Detalhes bibliográficos
Main Authors: Hessell, Ann J., Rakasz, Eva G., Tehrani, David M., Huber, Michael, Weisgrau, Kimberly L., Landucci, Gary, Forthal, Donald N., Koff, Wayne C., Poignard, Pascal, Watkins, David I., Burton, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812338/
https://ncbi.nlm.nih.gov/pubmed/19906907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01272-09
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