An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10

The membrane-proximal external region (MPER) of human immunodeficiency virus type 1 (HIV-1) gp41 bears the epitopes of two broadly neutralizing antibodies (Abs), 2F5 and 4E10, making it a target for vaccine design. A third Ab, Fab Z13, had previously been mapped to an epitope that overlaps those of...

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Detalhes bibliográficos
Main Authors: Nelson, Josh D., Brunel, Florence M., Jensen, Richard, Crooks, Emma T., Cardoso, Rosa M. F., Wang, Meng, Hessell, Ann, Wilson, Ian A., Binley, James M., Dawson, Philip E., Burton, Dennis R., Zwick, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866125/
https://ncbi.nlm.nih.gov/pubmed/17287272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02588-06
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