A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

The membrane-proximal external region (MPER) of the human immunodeficiency virus (HIV) envelope glycoprotein (gp41) is critical for viral fusion and infectivity and is the target of three of the five known broadly neutralizing HIV type 1 (HIV-1) antibodies, 2F5, Z13, and 4E10. Here, we report the cr...

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Détails bibliographiques
Auteurs principaux: Pejchal, Robert, Gach, Johannes S., Brunel, Florence M., Cardoso, Rosa M., Stanfield, Robyn L., Dawson, Philip E., Burton, Dennis R., Zwick, Michael B., Wilson, Ian A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738203/
https://ncbi.nlm.nih.gov/pubmed/19515770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00685-09
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