Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

The recent identification of three broadly neutralizing antibodies (bnAbs) against gp120–gp41 interface epitopes has expanded the targetable surface on the HIV-1 envelope glycoprotein (Env) trimer. By using biochemical, biophysical and computational methods, we map the previously unknown trimer epit...

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發表在:Nat Commun
Main Authors: Lee, Jeong Hyun, Leaman, Daniel P., Kim, Arthur S., Torrents de la Peña, Alba, Sliepen, Kwinten, Yasmeen, Anila, Derking, Ronald, Ramos, Alejandra, de Taeye, Steven W., Ozorowski, Gabriel, Klein, Florian, Burton, Dennis R., Nussenzweig, Michel C., Poignard, Pascal, Moore, John P., Klasse, Per Johan, Sanders, Rogier W., Zwick, Michael B., Wilson, Ian A., Ward, Andrew B.
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586043/
https://ncbi.nlm.nih.gov/pubmed/26404402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9167
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