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Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope
Antibody Z13e1 is a relatively broadly neutralizing anti-HIV-1 antibody that recognizes the membrane proximal external region (MPER) of the HIV-1 envelope (Env) glycoprotein gp41. Based on the crystal structure of an MPER epitope peptide in complex with Z13e1 Fab, we identified an unrelated protein,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3245871/ https://ncbi.nlm.nih.gov/pubmed/22033480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.014 |
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