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Directed Evolution of Mutator Adenoviruses Resistant to Antibody Neutralization
We incorporated a previously identified mutation that reduces the fidelity of the DNA polymerase into a human adenovirus vector. Using this mutator vector, we demonstrate rapid selection of resistance to a neutralizing anti-hexon monoclonal antibody due to a G434D mutation in hexon that precludes an...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3648140/ https://ncbi.nlm.nih.gov/pubmed/23487468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00473-13 |
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