Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

Influenza A virus (IAV), a major cause of human morbidity and mortality, continuously evolves in response to selective pressures. Stem-directed, broadly neutralizing antibodies (sBnAbs) targeting the influenza virus hemagglutinin (HA) are a promising therapeutic strategy, but neutralization escape m...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Prachanronarong, Kristina L., Canale, Aneth S., Liu, Ping, Somasundaran, Mohan, Hou, Shurong, Poh, Yu-Ping, Han, Thomas, Zhu, Quan, Renzette, Nicholas, Zeldovich, Konstantin B., Kowalik, Timothy F., Kurt-Yilmaz, Nese, Jensen, Jeffrey D., Bolon, Daniel N. A., Marasco, Wayne A., Finberg, Robert W., Schiffer, Celia A., Wang, Jennifer P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321927/
https://ncbi.nlm.nih.gov/pubmed/30381484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01639-18
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